期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 17, 页码 5294-5298出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201600812
关键词
alcohols; asymmetric catalysis; enantioselectivity; kinetic resolution; ruthenium
资金
- Slovenian Research Agency [P1-0242]
- French-Slovenian research collaboration Proteus
CF3-substituted 1,3-diols were stereoselectively prepared in excellent enantiopurity and high yield from CF3-substituted diketones by using an ansa-ruthenium(II)-catalyzed asymmetric transfer hydrogenation in formic acid/triethylamine. The intermediate mono-reduced alcohol was also obtained in very high enantiopurity by applying milder reaction conditions. In particular, CF3C(O)-substituted benzofused cyclic ketones underwent either a single or a double dynamic kinetic resolution during their reduction.
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