期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 51, 页码 15783-15786出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201608371
关键词
carbenes; halogens; olefination; organocatalysis; radicals
资金
- Hong Kong RGC [16304115, ECS605812, M-HKUST607/12]
- Fundamental Research Funds for the Central Universities
- Hunan University
- Shenzhen STIC [JCYJ20160229205441091]
An N-heterocyclic carbene (NHC) catalyzed dihalomethylenation of enals is described. It is a rare example of merging NHC catalysis with single-electron chemistry, a challenging topic with limited previous success. The versatile carbon-centered trihalomethyl radicals have been demonstrated, for the first time, to be compatible with an NHC-bound intermediate, thus leading to efficient and regioselective intermolecular C-C bond formation. The mild process provides straightforward access to unsaturated ,-dihalo esters.
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