期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 49, 页码 15406-15410出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201609853
关键词
aminocyclopropanes; asymmetric catalysis; cyclopropenes; hydroamination; lanthanide complexes
资金
- JSPS [26220802]
- Grants-in-Aid for Scientific Research [26220802] Funding Source: KAKEN
The search for efficient and selective routes for the synthesis of chiral aminocyclopropane derivatives is of great interest and importance as these structures are important components of biologically active natural products and pharmaceuticals. We herein report the enantioselective intermolecular hydroamination of substituted cyclopropenes with various amines catalyzed by chiral half-sandwich rare-earth-metal complexes. This method constitutes a 100% atom-efficient route for the synthesis of a variety of chiral -aminocyclopropane derivatives in high yields (up to 96%) and excellent stereoselectivity (up to >20:1 d.r. and 99% ee) under mild reaction conditions (25 degrees C).
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