期刊
ACS CATALYSIS
卷 9, 期 5, 页码 3906-3912出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b00470
关键词
copper; arylhydroxylamines; vinyliodonium salts; rearrangement; indoles
资金
- Shandong University
- National Natural Science Foundation of China [21702122]
- Natural Science Foundation of Shandong Province [ZR2017MB002]
Herein, we developed a copper-catalyzed O-vinylation of arylhydroxylamine using vinyliodonium salts as vinylation reagents to generate a transient O-vinyl-N-arylhydroxylamine that rapidly undergoes a [3,3]-sigmatropic rearrangement and subsequent cyclization/rearomatization to form a substituted indole. A wide range of highly substituted indoles and benzoindoles can be afforded in good yields. This approach is readily scalable, and the scope and application of this process are presented.
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