期刊
ACS CATALYSIS
卷 9, 期 4, 页码 3260-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b00181
关键词
palladium; directing group; carboboration; enantioselective catalysis; MOX ligand
资金
- TSRI
- Pfizer, Inc.
- Bristol-Myers Squibb
- National Institutes of Health [5R35GM125052-02]
- Nankai University College of Chemistry
A substrate-directed enantioselective anti-carboboration reaction of alkenes has been developed, wherein a carbon-based nucleophile and a boron moiety are installed across the C=C bond through a five-membered palladacycle intermediate. A preliminary result also shows it is possible to extend this reaction to alkenes that are more distal from the directing group and react via a six-membered palladacycle. The reaction is promoted by a palladium(II) catalyst and a monodentate oxazoline ligand. A range of enantioenriched secondary alkylboronate products were obtained with moderate to high enantioselectivity that could be further upgraded by recrystallization. This work represents an efficient method to synthesize versatile and valuable alkylboronate building blocks. Building on an earlier mechanistic proposal by He, Peng, and Chen, a revised model is proposed to account for the stereoconvergent nature of this transformation.
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