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D. J. Huels et al.
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Andreas E. Moor et al.
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Simon J. Leedham et al.
GUT (2013)
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Jiyeon Hyeon et al.
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M. Christie et al.
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Vivian S. W. Li et al.
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Hans Clevers et al.
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Donna M. Muzny et al.
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Kohichi Takada et al.
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Piero Dalerba et al.
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Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas
Juergen Deka et al.
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Hugo J. Snippert et al.
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Linda Madisen et al.
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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
Seth A. Ettenberg et al.
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Carlos Lopez-Garcia et al.
SCIENCE (2010)
BCL9 Promotes Tumor Progression by Conferring Enhanced Proliferative, Metastatic, and Angiogenic Properties to Cancer Cells
Mala Mani et al.
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BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration
Andrew S. Brack et al.
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The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression
Patrick Pollard et al.
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih-Min A. Huang et al.
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Toshiro Sato et al.
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Marc de la Roche et al.
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Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker et al.
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The intestinal Wnt/TCF signature
Laurens G. Van Der Flier et al.
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Crystal structure of a β-catenin/BCL9/Tcf4 complex
James Sampietro et al.
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Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract:: Effect of loss of β-catenin
H Ireland et al.
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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
F El Marjou et al.
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OJ Sansom et al.
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M Crabtree et al.
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Wnt/Wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear β-catenin-TCF complex
T Kramps et al.
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