相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice
Feifei Zhang et al.
HEPATOLOGY (2018)
Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21
Yixuan Sun et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency
Kaloyan M. Tsanov et al.
NATURE CELL BIOLOGY (2017)
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction
Junli Liu et al.
CELL (2016)
SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation
Manuel Roqueta-Rivera et al.
CELL METABOLISM (2016)
Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor α
Xuqing Chen et al.
DIABETES (2016)
Fibroblast Growth Factor 21 Improves Hepatic Insulin Sensitivity by Inhibiting Mammalian Target of Rapamycin Complex 1 in Mice
Qi Gong et al.
HEPATOLOGY (2016)
AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels
D. Grahame Hardie
ANNUAL REVIEW OF NUTRITION, VOL 34 (2014)
Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
Yu Li et al.
GASTROENTEROLOGY (2014)
AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
Ning Wu et al.
MOLECULAR CELL (2013)
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Morgan D. Fullerton et al.
NATURE MEDICINE (2013)
Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis
Tong-Fei Liu et al.
CELL METABOLISM (2012)
pVHL Mediates K63-Linked Ubiquitination of nCLU
Jing Xue et al.
PLOS ONE (2012)
The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
Simon A. Hawley et al.
SCIENCE (2012)
Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques
Jing-Jie Tang et al.
CELL METABOLISM (2011)
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
Yu Li et al.
CELL METABOLISM (2011)
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
Yu Li et al.
FASEB JOURNAL (2011)
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Maria M. Mihaylova et al.
NATURE CELL BIOLOGY (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
AMPK: Lessons from transgenic and knockout animals
Benoit Viollet et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
Dislocation of HMG-CoA Reductase and Insig-1, Two Polytopic Endoplasmic Reticulum Proteins, En Route to Proteasomal Degradation
Gil S. Leichner et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Clinical trial: insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis
R. Idilman et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2008)
Unsaturated Fatty Acids Inhibit Proteasomal Degradation of Insig-1 at a Postubiquitination Step
Joon No Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78
Joon No Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Liver adenosine monophosphate-activated kinase-α2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
F Andreelli et al.
ENDOCRINOLOGY (2006)
Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines
JN Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Protein sensors for membrane sterols
JL Goldstein et al.
CELL (2006)
Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake
Y Gong et al.
CELL METABOLISM (2006)
Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
LJ Engelking et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Metformin in the treatment of patients with non-alcoholic steatohepatitis
A Uygun et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2004)
Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
T Yang et al.
CELL (2002)
Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism
AJ Brown et al.
MOLECULAR CELL (2002)
Metformin in non-alcoholic steatohepatitis
G Marchesini et al.
LANCET (2001)
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
M Matsuda et al.
GENES & DEVELOPMENT (2001)
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene
M Amemiya-Kudo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
MS Brown et al.
CELL (2000)
Metformin reverses fatty liver disease in obese, leptin-deficient mice
HZ Lin et al.
NATURE MEDICINE (2000)