期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-019-08416-6
关键词
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资金
- National Science Foundation of China [21522104, 21431004, 21620102001, 21875136, 91856204]
- National Key Basic Research Program of China [2014CB932102, 2016YFA 0203400]
- Key Project of Basic Research of Shanghai [17JC1403100, 18JC1413200]
- Shanghai Eastern Scholar Program
The search for porous materials with strong Bronsted acid sites for challenging reactions has long been of significant interest, but it remains a formidable synthetic challenge. Here we demonstrate a cage extension strategy to construct chiral permanent porous hydrogen-bonded frameworks with strong Bronsted acid groups for heterogeneous asymmetric catalysis. We report the synthesis of two octahedral coordination cages using enantiopure 4,4', 6,6'-tetra(benzoate) ligand of 1,1'-spirobiindane-7,7'-phosphoric acid and Ni-4/Co-4-p-tert-butylsulfonylcalix[4]arene clusters. Intercage hydrogen-bonds and hydrophobic interactions between tert-butyl groups direct the hierarchical assembly of the cages into a permanent porous material. The chiral phosphoric acid-containing frameworks can be high efficient and recyclable heterogeneous Bronsted acid catalysts for asymmetric [3+2] coupling of indoles with quinone monoimine and Friedel-Crafts alkylations of indole with aryl aldimines. The afforded enantioselectivities (up to 99.9% ee) surpass those of the homogeneous counterparts and compare favorably with those of the most enantioselective homogeneous phosphoric acid catalysts reported to date.
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