期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 10, 期 3, 页码 228-236出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.8b00450
关键词
Allosteric modulation; ionotropic glutamate receptors (iGluRs); positive allosteric modulator (PAM); negative allosteric modulator (NAM); CNS-related disorders
The allosteric targeting of ionotropic glutamate receptors (iGluRs) is a valuable approach for treating various central nervous system (CNS) disorders. In this frame, this Innovations provides a summary of the state-of-the art in the development of allosteric modulators for iGluRs and offers an outlook regarding innovative strategies for treating neurological diseases.
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