期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 31, 页码 8869-8872出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602446
关键词
atomic force microscopy; DNA origami; DNA structures; molecular simulation
资金
- Swedish Research Council [2013-5883]
- Swedish Foundation for Strategic Research [FFL12-0219]
- Knut and Alice Wallenberg Foundation [KAW2014.0241]
- European Research Council [617791]
- Wallenberg Scholars grant
- Helsinki Doctoral Education Network on Information and Communications Technology (HICT)
- Swedish Foundation for Strategic Research (SSF) [FFL12-0219] Funding Source: Swedish Foundation for Strategic Research (SSF)
The use of DNA as a nanoscale construction material has been a rapidly developing field since the 1980s, in particular since the introduction of scaffolded DNA origami in 2006. Although software is available for DNA origami design, the user is generally limited to architectures where finding the scaffold path through the object is trivial. Herein, we demonstrate the automated conversion of arbitrary two-dimensional sheets in the form of digital meshes into scaffolded DNA nanostructures. We investigate the properties of DNA meshes based on three different internal frameworks in standard folding buffer and physiological salt buffers. We then employ the triangulated internal framework and produce four 2D structures with complex outlines and internal features. We demonstrate that this highly automated technique is capable of producing complex DNA nanostructures that fold with high yield to their programmed configurations, covering around 70% more surface area than classic origami flat sheets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据