期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 8, 页码 2738-2742出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510269
关键词
azobenzene; DNA structures; G-quadruplexes; IR spectroscopy; NMR spectroscopy
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB902]
- CLiC
- DFG [EXC 115, WA 1850/4-1]
- LOEWE project SynChemBio
- state of Hesse (BMRZ)
The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two-tetrad G-quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G-quadruplexes with K+ ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para-para-substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G-quadruplex and an unstructured state after E-Z isomerization.
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