期刊
JOURNAL OF FUNCTIONAL FOODS
卷 54, 期 -, 页码 81-91出版社
ELSEVIER
DOI: 10.1016/j.jff.2018.12.034
关键词
P. ostreatus; P. eryngii; Glucans; Inflammation; Inflammatory bowel disease; DSS-treated mice
资金
- BARD (Binational agricultural research and development fund) [IS -4851-15 R.]
We compared the immune-modulating activity of glucans extracted from P. ostreatus and P. eryngii on phagocytosis of peripheral blood neutrophils, and superoxide release from HL-60 cells. The results suggest that the anti-inflammatory properties of these glucans are partially mediated through modulation of neutrophil effector functions (P. eryngii was more effective). Additionally, both glucans dose-dependently competed for the antiDectin-1 and anti-CR3 antibody binding. We then tested the putative anti-inflammatory effects of the extracted glucans in inflammatory bowel disease (IBD) using the dextran sulfate sodium (DSS)-induced model in mice. The clinical symptoms of IBD were efficiently relieved by the treatment with two different doses of the glucan from both fungi. Glucan fractions, from either P. ostreatus or P. eryngii, markedly prevented TNF-alpha mediated inflammation in the DSS-induced inflamed intestine. These results suggest that there are variations in glucan preparations from different fungi in their anti-inflammatory ability.
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