期刊
JOURNAL OF FUNCTIONAL FOODS
卷 53, 期 -, 页码 22-27出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.12.012
关键词
Astaxanthin; Diabetes; Coagulation factors; Lipid profile; Inflammation
资金
- Ministry of Science and Technology, Taipei City, Taiwan [NSC 100-2320-B-126-001]
The anti-coagulatory effects of astaxanthin (AX) in type 2 diabetic patients were demonstrated. Diabetic patients were randomly assigned into three groups: placebo, low AX (L-AX, 6 mg AX/day) and high AX (H-AX, 12 mg AX/day). The plasma levels of coagulation factors including plasminogen activator inhibitor (PAI)-1 and factor VII (FVII); anticoagulation factors including antithrombin-III (AT-III) and protein C in diabetic patients were determined prior to intervention and 8 weeks after intervention. Plasma lipid profiles and inflammatory factors were also measured. AX supplements increased plasma AX levels and decreased FPG and HbA1c levels. H-AX intake lowered changes in plasma triglyceride, total cholesterol and LDL levels. AX supplements lowered changes in plasma IL-6 and TNF-alpha levels. H-AX decreased changes in plasma FVII and PAI-llevels. AX intake also led to lower changes in plasma vWF level and higher changes in AT-III level. AX supplementation appears to be helpful for the alleviation of diabetic coagulation disorders.
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