期刊
FRONTIERS IN CELLULAR NEUROSCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2019.00042
关键词
astrocytes; microglia; synapse loss; Alzheimer's disease; neurodegenerative diseases
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2016M3C7A1905391, NRF-2016R1C1B3006969, NRF-2018R1A4A1020922]
- Cure Alzheimer's Fund
- National Research Foundation of Korea [2016M3C7A1905391] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Glial cells are emerging as crucial players that mediate development and homeostasis of the central nervous system (CNS). In particular, glial cells are closely associated with synapses, and control synapse formation, function, plasticity, and elimination during the stages of development and adulthood. Importantly, it is now increasingly evident that abnormal glial function can be an active inducer of the initiation and progression of various neurodegenerative diseases. Here, we discuss recent developments on the physiological roles of glial cells in the brain, and propose that synapse loss, which is a common characteristic of several neurodegenerative diseases, can be initiated by mis-regulation of normal glial function.
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