期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 39, 页码 11979-11983出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201605090
关键词
beta-cyclodextrin; bile acids; biodegradable and thermoresponsive polymers; molecular necklace; polypseudorotaxanes
资金
- NSERC of Canada
- FQRNT of Quebec
- FQRNT
- FRSQ
A molecular necklace of polypseudorotaxanes was prepared by threading beta-cyclodextrins (beta-CD) onto biodegradable and thermoresponsive polyurethanes derived from bile acids. These polyurethanes were synthesized via a simple step condensation of bile acid-based dicarbonate with poly(ethylene glycol)-diamine. The beta-CD rings slide onto the poly(ethylene glycol) segments and selectively recognize the bile acid units of the polyurethane chains, whereas the poly(ethylene glycol) segments remain crystalline with a lower crystallinity. This bio-compound-derived molecular necklace can be visualized by scanning tunneling microscopy. The polypseudorotaxanes show thermosensitivity in water and the phase transition temperature may be fine-tuned by varying the molar ratios of beta-CD to the bile acid units. Such an interesting necklace model of polypseudorotaxane constructed from natural compounds may lead to the further exploration of their applications, such as as an enzyme model, due to their biological nature.
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