期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 30, 页码 8740-8743出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201604127
关键词
alkenes; copper; homogeneous catalysis; perfluoroalkylation; peroxide
资金
- JSPS KAKENHI [15K17860]
- RIKEN
- Grants-in-Aid for Scientific Research [15K17860] Funding Source: KAKEN
An efficient perfluoroalkylation of unactivated alkenes with perfluoro acid anhydrides was developed. Copper salts play a crucial role as a catalyst to achieve allylic perfluoroalkylation with the in situ generated bis(perfluoroacyl) peroxides. Furthermore, carboperfluoroalkylation of alkene bearing an aromatic ring at an appropriate position on the carbon side chain was found to proceed under metal-free conditions to afford carbocycles or heterocycles bearing a perfluoroalkyl group. This method, which makes use of readily available perfluoroalkyl sources, offers a convenient and powerful tool for introducing a perfluoroalkyl group onto an sp(3) carbon to construct synthetically useful skeletons.
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