期刊
VIRUSES-BASEL
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/v11030228
关键词
Hantaviridae; Mobatvirus; phylogeny
类别
资金
- Japan Agency for Medical Research and Development (AMED) [JP15fk0108005, JP16fk0108117, JP17fk0108217, JP18fk0108017]
- Japan Society for the Promotion of Science [24405045]
- NAFOSTED [106-NN.05-2016.14]
- VAST-JSPS [QTJP01.02/18-20]
- U.S. National Institutes of Health [P30GM114737]
- Grants-in-Aid for Scientific Research [24405045] Funding Source: KAKEN
The discovery of highly divergent lineages of hantaviruses (family Hantaviridae) in shrews, moles, and bats of multiple species raises the possibility that non-rodent hosts may have played a significant role in their evolutionary history. To further investigate this prospect, total RNA was extracted from RNAlaterA (R)-preserved lung tissues of 277 bats (representing five families, 14 genera and 40 species), captured in Myanmar and Vietnam during 2013-2016. Hantavirus RNA was detected in two of 15 black-bearded tomb bats (Taphozous melanopogon) and two of 26 Pomona roundleaf bats (Hipposideros pomona) in Myanmar, and in three of six ashy leaf-nosed bats (Hipposideros cineraceus) in Vietnam. Pair-wise alignment and comparison of coding regions of the S, M, and L segments of hantaviruses from Taphozous and Hipposideros bats revealed high nucleotide and amino acid sequence similarities to prototype Laibin virus (LAIV) and Xuan S;n virus (XSV), respectively. Phylogenetic analyses, generated by maximum-likelihood and Bayesian methods, showed a geographic clustering of LAIV strains from China and Myanmar, but not of XSV strains from China and Vietnam. These findings confirm that the black-bearded tomb bat is the natural reservoir of LAIV, and that more than one species of Hipposideros bats can host XSV.
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