期刊
VIRUSES-BASEL
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/v11030253
关键词
(+)ssRNA viruses; RNA packaging; virion assembly; packaging signals; RNA replication
类别
资金
- SECRETARIA DE EDUCACION PUBLICA DE MEXICO (SEP) through the NPTC PRODEP Program [511-6/18-8708 UASLP-PTC-622]
- Autonomous University of San Luis Potosi (UASLP) through the FAI program [C18-FAI-05-14.14]
The packaging of genomic RNA in positive-sense single-stranded RNA viruses is a key part of the viral infectious cycle, yet this step is not fully understood. Unlike double-stranded DNA and RNA viruses, this process is coupled with nucleocapsid assembly. The specificity of RNA packaging depends on multiple factors: (i) one or more packaging signals, (ii) RNA replication, (iii) translation, (iv) viral factories, and (v) the physical properties of the RNA. The relative contribution of each of these factors to packaging specificity is different for every virus. In vitro and in vivo data show that there are different packaging mechanisms that control selective packaging of the genomic RNA during nucleocapsid assembly. The goals of this article are to explain some of the key experiments that support the contribution of these factors to packaging selectivity and to draw a general scenario that could help us move towards a better understanding of this step of the viral infectious cycle.
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