期刊
VIRUSES-BASEL
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/v11020129
关键词
zoonosis; host adaptation; evolution; genome recombination; respiratory pathogens; civilian populations; human adenovirus type 4
类别
资金
- National Natural Science Foundation of China [31570155, 31370199]
- Guangzhou Healthcare Collaborative Innovation Major Project [201803040004, 201803040007]
Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these old HAdV-E4 is the absence of a critical replication motif, NF-I, which is found in all HAdV respiratory pathogens and most HAdVs. However, our recent survey of flu-like disease in children in Hong Kong reveals that the emergent HAdV-E4 pathogens circulating in civilian populations contain NF-I, indicating recombination and reflecting host-adaptation that enables the new HAdV-E4 to replicate more efficiently in human cells and foretells more potential HAdV-E4 outbreaks in immune-naive civilian populations. Special attention should be paid by clinicians to this emergent and recombinant HAdV-E4 circulating in civilian populations.
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