期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 52, 页码 16168-16171出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201608516
关键词
NMR spectroscopy; protein structures; transthyretin
资金
- Alexander von Humboldt Foundation
- Marie Curie Intra-European fellowship [626526]
Mutations in the protein transthyretin can cause as well as protect individuals from transthyretin amyloidosis, an incurable fatal inherited disease. Little is known, however, about the structural basis of pathogenic and clinically protective transthyretin mutants. Here we determined the solution structure of a transthyretin monomer that carries the clinically important T119M mutation. The structure displays a non-native arrangement that is distinct from all known structures of transthyretin and highlights the importance of high-resolution studies in solution for understanding molecular processes that lead to amyloid diseases.
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