期刊
WASTE MANAGEMENT
卷 84, 期 -, 页码 141-146出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.wasman.2018.11.039
关键词
Antibiotics; Antibiotic resistance genes; Ionizing radiation; Antibiotic fermentation residues; Antibiotic resistant bacteria
资金
- National Natural Science Foundation of China [21777083]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT-13026]
Antibiotic fermentation residues are a kind of hazardous waste due to the existence of the residual antibiotics and the potential risk to generate antibiotics resistance genes (ARGs). The appropriate treatment and disposal of antibiotic fermentation residues is imperative. In this study ionizing radiation was applied to treat the antibiotic fermentation residues and the removal efficiencies of antibiotic (erythromycin), ARGs (ermB and ermF) and antibiotic resistant bacteria were investigated. The experimental results showed that erythromycin A content in antibiotic fermentation residues decreased by 86% when the dose was 10 kGy. Moreover, the abundance of ermB and ermF reduced by 89% and 98% at 10 kGy irradiation. Over 99% of total bacteria was removed and antibiotic resistant bacteria (ARB) were less than detection limit after 10 kGy irradiation. Ionizing radiation process is a promising technology for simultaneously removing antibiotic and inactivating ARGs and ARB in antibiotic fermentation residues. Moreover, the irradiation at 10 kGy had no significant influence on the macromolecules organic matters (protein, polysaccharides) of the antibiotic fermentation residues, suggesting that the treated fermentative residues can be used as fertilizer, which could provide the technical support for the development of recycling economy in antibiotic pharmaceutical factory. (C) 2018 Elsevier Ltd. All rights reserved.
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