期刊
VIRUS RESEARCH
卷 265, 期 -, 页码 143-149出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2019.03.023
关键词
Virus; Transmission; Extracellular vesicle; En bloc; Quasispecies; RNA virus; DNA virus; Fitness; Virulence; Population; Multiplicity of infection; Exosome; Phosphatidylserine
类别
资金
- Miguel Servet program of the Instituto de Salud carlos III - European Regional Development fund (ERDF) [CP14/00121]
- Instituto de Salud Carlos III
- Ministerio de Economia y Competitividad [SAF2014-52400-R]
- Ministerio de Ciencia, Innovacion y Universidades [SAF2017-87846-R, BFU2017-91384-EXP, PI18/00210]
- PLATESA from Comunidad de Madrid/FEDER [S2013/ABI-2906]
- PLATESA2 from Comunidad de Madrid/FEDER [P2018/BAA-4370]
- Fundacion Ramon Areces
- Banco Santander
- National Institutes of Health intramural program
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [ZIAHL006234] Funding Source: NIH RePORTER
En Bloc transmission of viruses allow multiple genomes to collectivelly penetrate and initiate infection in the same cell, often resulting in enhanced infectivity. Given the quasispecies (mutant cloud) nature of RNA viruses and many DNA viruses, en bloc transmission of multiple genomes provides different starting points in sequence space to initiate adaptive walks, and has implications for modulation of viral fitness and for the response of viral populations to lethal mutagenesis. Mechanisms that can enable multiple viral genomes to be transported en bloc among hosts has only recently been gaining attention. A growing body of research suggests that extracellular vesicles (EV) are highly prevalent and robust vehicles for en bloc delivery of viral particles and naked infectious genomes among organisms. Both RNA and DNA viruses appear to exploit these vesicles to increase their multiplicity of infection and enhance virulence.
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