期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 17, 页码 5342-5345出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201600783
关键词
enzyme models; flavins; oxidative; chlorination photocatalysis
资金
- Deutsche Forschungsgemeinschaft (DFG) [GRK 1626]
- Fonds der Chemischen Industrie
Chlorine gas or electropositive chlorine reagents are used to prepare chlorinated aromatic compounds, which are found in pharmaceuticals, agrochemicals, and polymers, and serve as synthetic precursors for metal-catalyzed cross-couplings. Nature chlorinates with chloride anions, FAD-dependent halogenases, and O-2 as the oxidant. A photocatalytic oxidative chlorination is described based on the organic dye riboflavin tetraacetate mimicking the enzymatic process. The chemical process allows within the suitable arene redox potential window a broader substrate scope compared to the specific activation in the enzymatic binding pocket.
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