期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 45, 期 2, 页码 471-480出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2018.10.020
关键词
Papillary thyroid carcinoma; Hashimoto's thyroiditis; conventional ultrasound; acoustic radiation force impulse; contrast-enhanced ultrasound
资金
- National Natural Science Foundation of China [81401431]
- Hunan Provincial Natural Science Foundation of China [2017 JJ3443, 2018 JJ2575]
Our objective was to provide the various sonographic characteristics of papillary thyroid carcinomas for Hashimoto's thyroiditis (HT) patients, including conventional ultrasound (US), acoustic radiation force impulse Virtual Touch imaging and quantification (ARFI-VTIQ) and contrast-enhanced ultrasound (CEUS). Sixty-nine HT patients with 85 thyroid nodules (TNs) (49 malignant and 36 benign) were enrolled in this study. We evaluated the size, shape, margin, echogenicity, presence of halo, calcification, vascularity and ARFI-VTIQ and CEUS parameters for each nodule and compared the findings with the reference standards of histopathological and/or cytologic results. Univariate analysis indicated that compared with benign TNs with HT, papillary thyroid carcinomas with HT more often had taller-than-wider shapes, ill-defined margins, microcalcifications, peripheral vascularity, relatively harder stiffness with a higher shear wave speed, hypo-enhancement, peak intensity index <1 and area under the curve index <1 at pre-operative US, ARFI-VTIQ and CEUS. Multivariate analysis revealed that ill-defined margins, microcalcifications and peak intensity index <1 are independent characteristics related to malignant TNs for their differentiation from benign TNs (all p < 0.05). Our study indicated that pre-operative multiparameter US characteristics may serve as a useful tool to identify malignant TNs in HT patients. (C) 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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