期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 45, 期 5, 页码 1274-1283出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2018.12.012
关键词
Focused ultrasound; Ultrasound stimulation; Neuromodulation; Hippocampal neurons; Primary cilia
资金
- National Key R&D Program of China [2016YFC0104700]
- National Natural Science Foundation of China [81527901, 11774371, 11674347, 11574341, 11534013]
- Natural Science Foundation of Guangdong Province [2017B030306011]
- Youth Innovation Promotion Association CAS [2018393]
- Shenzhen Basic Science Research [JCYJ20160429184552717]
Transcranial modulation of primary cilia may provide new opportunities in the treatment of neurode-generative diseases. This study investigates the effect of non-invasive low-intensity pulsed ultrasound (LIPUS) stimulation on primary cilia of rat hippocampal neurons. Three hours of LIPUS stimulation significantly reduced the incidence rate and length of cilia on cultured neurons (p < 0.01). Similarly, increasing the duration and intensity of LIPUS stimulation decreased the incidence and length of cilia. LIPUS stimulation improved c-fos expression when it was delivered to CA1 of the intact hippocampus of rats. And prolonged LIPUS stimulation (frequency: 0.5 MHz, pulse repetition frequency: 500 Hz, duty cycle: 5%, I-spta: 255 mW/cm(2), 10 min/d, 10 d) caused a statistically significant reduction in the incidence rate (p < 0.05) and length of primary cilia (p < 0.01) of neurons in rat CA1 hippocampus. These results indicate the promising potential of LIPUS stimulation in the treatment of primary cilium-related brain diseases. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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