A rapid ultrasonic energy assisted preconcentration method for simultaneous extraction of lead and cadmium in various cosmetic brands using deep eutectic solvent: A multivariate study

An innovative ultrasonic assisted microextraction method using a deep eutectic solvent for entrapping the organ metallic complexes was developed to pre-concentrate the trace quantities of cadmium (Cd) and lead (Pb) in lipsticks and eye shadows of different brands prior to flame atomic absorption spectrometry analysis. A deep eutectic solvent (DES) was used in this study, prepared by mixing metal salt (ZnCl2) and hydrogen bond donors such as (acetamide) in different ratio. The different branded cosmetic items, lipstick and eye shadows, obtained from local market and subjected to acid digestion prior to application of proposed ultrasonic assisted micro extraction method based on deep eutectic solvent (UA mu E-DES) with the aid of mechanical and ultrasound energies. Ammonium pyrrolidine dithiocarbamate was used as a ligand to made hydrophobic complexes of Cd and Pb, entrapped in DES in the presence of aprotic solvent. The seven variables, mixing ratio of ZnCl2 and Acetamide, DES volume, Ultrasound and Conventional shaking time, pH, tetrahydrofuran and complexing reagent volume were optimized by multivariate approach for the optimum recovery of Cd and Pb from real cosmetic items. The resulted data indicates that ultrasound energy assisted extraction time, volume of DES and pH were most significant variables. The precision and validity of developed procedure were checked by the spiked known certified standards in real samples. The resulted data indicated that the lipsticks have different glittering colors contains high contents of Pb and Cd, whereas dark colors of eye shadows contain high level of both elements.