期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 7, 页码 2559-2563出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510638
关键词
arylation; homogeneous catalysis; ketones; palladium; synthetic methods
资金
- CPRIT
- Welch Foundation [F 1781]
- USTC
Direct arylation of cyclopentanones has been a longstanding challenge because of competitive self-aldol condensation and multiple arylations. Reported herein is a direct mono-a-C-H arylation of cyclopentanones with aryl bromides which is enabled by palladium/amine cooperative catalysis. This method is scalable and chemoselective with broad functional-group tolerance. Application to controlled sequential arylation of cyclopentanones has been also demonstrated.
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