期刊
TRENDS IN MOLECULAR MEDICINE
卷 25, 期 4, 页码 315-327出版社
CELL PRESS
DOI: 10.1016/j.molmed.2019.02.004
关键词
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资金
- ARC Tier 2 grant from the Ministry of Education, Singapore [MOE2014-T2-1-133]
- NUS Graduate School for Integrative Sciences and Engineering
Annexin-A1 (ANXA1), a potent endogenous immunomodulatory protein has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion. ANXA1 expression is varied depending on tumor type, and there are contradictory reports on its role in the regulation of proliferation and tumor growth. Here, we summarize the differing reports on cell proliferation and metastasis and attempt to discuss the reasons behind these different effects. ANXA1 plays a role as a homeostatic protein that regulates essential transcription factors and miRNAs. A more coherent understanding of ANXA1 in cancer could present a more biologically meaningful and clinically relevant strategy.
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