期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 30, 期 5, 页码 312-327出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2019.02.006
关键词
-
资金
- ERC Advanced Investigator Grant [294683 RadMed]
- ERC proof-of-concept grant [139-101052 -SAVEBRAIN]
- EU Horizon 2020 programme, REPOTRIAL
- National Health and Medical Research Council
- Spanish Ministry of Economy and Competitiveness [SAF2016-76520-R]
- European Regional Development Fund [P_37_732/2016 REDBRAIN]
- Competitiveness Operational Program 2014-2020
Reactive oxygen species (ROS) have been mainly viewed as unwanted by-products of cellular metabolism, oxidative stress, a sign of a cellular redox imbalance, and potential disease mechanisms, such as in diabetes mellitus (DM). Antioxidant therapies, however, have failed to provide clinical benefit. This paradox can be explained by recent discoveries that ROS have mainly essential signaling sources. Disease can occur when ROS accumulate in nonphysiological concentrations, locations, or forms. By focusing on disease-relevant sources and targets of ROS, and leaving ROS physiology intact, precise therapeutic interventions are now possible and are entering clinical trials. Their outcomes are likely to profoundly change our concepts of ROS in DM and in medicine in general.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据