期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 50, 页码 15520-15523出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201608354
关键词
bioinorganic chemistry; ethenoadenine; metal bioconjugates; metal-mediated base pair; mercury
资金
- DFG [SFB 858]
- NRW Graduate School of Chemistry
- COST Action [CM1105]
The first dinuclear metal-mediated base pair containing divalent metal ions has been prepared. A combination of the neutral bis(monodentate) purine derivative 1,N-6-ethenoadenine (epsilon A), which preferentially binds two metal ions with a parallel alignment of the N-M bonds, and the canonical nucleobase thymine (T), which readily deprotonates in the presence of Hg-II and thereby partially compensates the charge accumulation due to the two closely spaced divalent metal ions, yields the dinuclear T-Hg-2(II)-epsilon A base pair. This metal-mediated base pair stabilizes the DNA oligonucleotide duplex as shown by an increase of 8 degrees C in its melting temperature. Formation of the base pair was demonstrated by temperature-dependent UV spectroscopy as well as by titration experiments monitored by UV and CD spectroscopy.
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