4.8 Article

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis

期刊

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 35, 页码 10278-10282

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201604126

关键词

antimicrobial activity; combined; cultures; natural products; structure elucidation; total synthesis

资金

  1. Japan Society for the Promotion of Science (JSPS)
  2. Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
  3. Japan Agency for Medical Research and Development (AMED)
  4. Institute for Fermentation, Osaka (IFO)
  5. Grants-in-Aid for Scientific Research [25702048, 16K18673, 15K14721] Funding Source: KAKEN

向作者/读者索取更多资源

A series of lipidic spirohemiaminals, designated streptoaminals, is reported. These were discovered by surveying the unique molecular signatures identified in the mass spectrometry data of the combined-culture broth of Streptomyces nigrescens HEK616 and Tsukamurella pulmonis TP-B0596. Mass spectrometry analysis showed that streptoaminals appeared as a cluster of ion peaks, which were separated by 14 mass unit intervals, implying the presence of alkyl chains of different lengths. The chemical structures of these compounds were elucidated by spectroscopic analysis and total synthesis. Streptoaminals with globular structures showed broad antimicrobial activities, whereas the planar structures of the 5-alkyl-1,2,3,4-tetrahydroquinolines found in the same combined-culture did not. This work shows the application of microbes as reservoirs for a range of chemical scaffolds.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据