期刊
TRAFFIC
卷 20, 期 6, 页码 373-379出版社
WILEY
DOI: 10.1111/tra.12644
关键词
intrinsically disordered regions; liquid phase separation; non-membrane-bound organelles; P granules
类别
资金
- NIGMS NIH HHS [F32 GM128248, R01 GM113933, P20 GM103423] Funding Source: Medline
Membraneless organelles are distinct compartments within a cell that are not enclosed by a traditional lipid membrane and instead form through a process called liquid-liquid phase separation. Examples of these non-membrane-bound organelles include nucleoli, stress granules, P bodies, pericentriolar material and germ granules. Many recent studies have used Caenorhabditis elegans germ granules, known as P granules, to expand our understanding of the formation of these unique cellular compartments. From this work, we know that proteins with intrinsically disordered regions (IDRs) play a critical role in the process of phase separation. IDR phase separation is further tuned through their interactions with RNA and through protein modifications such as phosphorylation and methylation. These findings from C elegans, combined with work done in other model organisms, continue to provide insight into the formation of membraneless organelles and the important role they play in compartmentalizing cellular processes.
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