期刊
TETRAHEDRON LETTERS
卷 60, 期 17, 页码 1166-1169出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2019.03.052
关键词
Acridine; Antimalarial; Heteroaromatic; Heterocyclic chemistry; Mepacrine; Quinacrine
资金
- Fundacao para a Ciencia e Tecnologia (FCT, Portugal) [UID/QUI/50006/2013, PTDC/BTM-SAL/29786/2017]
- Comissao de Coordenacao e Desenvolvimento Regional do Norte (CCDR-N)/NORTE2020/Portugal2020 [NORTE-01-0145-FEDER-000024]
- Fundação para a Ciência e a Tecnologia [PTDC/BTM-SAL/29786/2017] Funding Source: FCT
A multi-step synthetic route towards N-4,N-9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection. (C) 2019 Elsevier Ltd. All rights reserved.
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