期刊
TECHNIQUES IN COLOPROCTOLOGY
卷 23, 期 2, 页码 129-134出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10151-019-1928-0
关键词
Sarcopenia; Colorectal neoplasms; Postoperative complications; Anastomotic leak
资金
- Royal College of Surgeons of England
- Dunhill Medical Trust
BackgroundRadiologically defined sarcopenia has been shown to predict negative outcomes after cancer surgery, however radiological assessment of sarcopenia often requires additional software and standardisation against anthropomorphic data. Measuring psoas density using hospital Picture Archiving and Communication Systems (PACS), universally available in the UK, may have advantages over methods requiring the use of additional specialist and often costly software. The aim of this study was to assess the association between radiologically defined sarcopenia measured by psoas density and postoperative outcome in patients having a colorectal cancer resection.MethodsAll patients having a resection for colorectal cancer, discussed by the colorectal multi-disciplinary team in one institution between 1/1/15 and 31/12/15, were retrospectively identified. Mean psoas density at the level of the L3 vertebra was analysed from preoperative computed tomography (CT) scans to define sarcopeniausingthe Picture Archiving and Communication Systems (PACS). Postoperative complications and mortality were recorded.ResultsOne hundred and sixty-nine patients had a colorectal resection for cancer and 140 of these had a primary anastomosis. Ninety-day mortality and 1-year mortality were 1.1% and 7.1%, respectively. Eighteen (10.7%) patients suffered a Clavien-Dindo grade 3 or 4 complication of which 6 (33%) were anastomotic leaks. In the whole cohort, sarcopenia was associated with an increased risk of Clavien-Dindo grade 3 or 4 complications [adjusted OR 6.33 (1.65-24.23) p=0.007]. In those who had an anastomosis, sarcopenia was associated with an increased risk of anastomotic leak [adjusted OR 14.37 (1.37-150.04) p=0.026].ConclusionsA quick and easy radiological assessment of sarcopenia by measuring psoas density on preoperative CT scan using software universally available in the UKis highly predictive of postoperative morbidity in colorectal cancer patients.
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