期刊
TALANTA
卷 194, 期 -, 页码 38-45出版社
ELSEVIER
DOI: 10.1016/j.talanta.2018.09.104
关键词
Excited-state intramolecular proton transfer (ESIPT) effect; Self-assemble nanoparticles; Fluorescent probe; Aluminum bioimaging
资金
- National Natural Science Foundation of China [81741134, 81671756, 81771827, 81471715]
- Science and Technology Foundation of Hunan Province [2017SK2093, 2018JJ2064]
- State Key Laboratory of Drug Research [SIMM1803KF-14]
- Innovation Fund for Postgraduate Students of Central South University [2018zzts866]
Aluminum ions, as a kind of non-essential element, show a negative impact on plants growth and contribute to diseases caused by nervous breakdown like Alzheimer's disease and Parkinson's disease. Hence, the detection of Al3+ in environment and human body is of great significance and valuableness. Herein, a N-H-type excited-state intramolecular proton transfer (ESIPT) based self-assemble nanoprobe has been designed and synthesized for the detection of Al3+. Owing to phthalandione and tosyl group, probe ABTTA could self-assemble into nanoparticles with nearly no fluorescence. However, ABTTA would be further aggregated by Al3+ ions in aqueous solution which results in enhanced fluorescence (peaking at 555 nm). Based on this principle, a novel analytical method for detection of Al3+ was established with a limit of detection of 50 nM, which was much better than most of reported probes. Moreover, the nanoprobe with excellent water solubility was successfully applied for the detection of Al3+ in real water sample with satisfactory measurement accuracy. Benefited from the favorable water solubility, the nanoprobe was further utilized to the detection of Al3+ in human cancer samples, demonstrating its potential application for biological imaging.
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