期刊
STATISTICS IN MEDICINE
卷 38, 期 14, 页码 2589-2604出版社
WILEY
DOI: 10.1002/sim.8135
关键词
area under the ROC curve; Bayes-risk consistency; fisher consistency; integrated discrimination improvement; logistic regression; net reclassification index
类别
资金
- Japan Society for the Promotion of Science (JSPS) KAKENHI [15K15950]
The predictive performance of biomarkers is a central concern in biomedical research. This is often evaluated by comparing two statistical models: a new model incorporating additional biomarkers and an old model without them. In 2008, the integrated discrimination improvement (IDI) was proposed for cases when the response variable is binary, and it is now widely applied as a promising alternative to conventional measures, such as the difference of the area under the receiver operating characteristic curve. However, the IDI can erroneously identify a significant improvement in the new model even if no additional information has been provided by new biomarkers. In order to overcome problems with existing measures, in this study, we propose the power-IDI as a measure of incremental predictive value. Our study explains why the IDI cannot avoid false detection of apparent improvements in a new model and we show that our proposed measure is better able to capture improvements in prediction. Numerical simulations and examples using real empirical data reveal that the power-IDI is not only more powerful but also incurs fewer false detections of improvement.
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