期刊
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
卷 14, 期 3, 页码 319-327出版社
OXFORD UNIV PRESS
DOI: 10.1093/scan/nsz008
关键词
social well-being; dispositional forgiveness; personality; individual differences; orbitofrontal cortex; voxel-based morphometry
资金
- National Natural Science Foundation of China [31800942, 31700945]
- Young Talent Fund of University Association for Science and Technology in Shaanxi, China [20180206]
- Fundamental Research Funds for the Central Universities [GK201903106]
Social well-being reflects the perception of one's social functioning, which plays an important role in physical and psychological health. However, the exact neuroanatomical substrate for social well-being remains unclear. To address the issue, we employed the voxel-based morphometry method to probe the neuroanatomical basis of individual variation in social well-being in young healthy adults (n=136). The results revealed a significant negative association between social well-being and regional gray matter density (rGMD) in an anatomical cluster that mainly includes the left orbitofrontal cortex (OFC) that has been involved in emotion regulation and social cognition. Furthermore, a balanced 4-fold cross-validation using the machine learning approach revealed that rGMD in the left OFC could be reliably related to social well-being. More importantly, the multiple mediation analysis revealed that neuroticism and dispositional forgiveness independently mediated the association between rGMD in the left OFC and social well-being. In addition, all these results remained stable when subjective socioeconomic status was controlled. Together, our results provide the initial evidence that the OFC is a neuroanatomical substrate for social well-being and demonstrate that the OFC is a crucial neural site linking neuroticism and dispositional forgiveness to social well-being.
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