期刊
SMALL
卷 15, 期 13, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201900056
关键词
barcode; colloidal crystal; microfluidics; multiplex detection; structural color
类别
资金
- National Key Research and Development Program of China [2017YFA0700404]
- National Natural Science Foundation of China [21473029, 51522302]
- NSAF Foundation of China [U1530260]
- National Science Foundation of Jiangsu [BK20180128]
- Scientific Research Foundation of Southeast University
- Scientific Research Foundation of Graduate School of Southeast University
Barcode particles have a demonstrated value for multiplexed high-throughput bioassays. Here, a novel photonic crystal (PhC) barcode is presented that consists of hollow colloidal nanospheres assembled through microfluidic droplet templates. Due to their gas-filled core, the resultant barcode particles not only show increased refractive index contrast, but also remain in suspension by adjusting the overall density of the PhC to match that of a detection solution. In addition, magnetic nanoparticles can be integrated to give the barcodes a magnetically controllable motion ability. The encoding ability of the barcodes is demonstrated in microRNA detection with high specificity and sensitivity, and the excellent features of the barcodes make them potentially very useful for biomedical applications.
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