期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 282, 期 -, 页码 158-163出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.11.047
关键词
Dual-frequency liquid crystal; Dielectric spectroscopy; Protein; Bovine serum albumin; LC-based biosensor
资金
- Ministry of Science and Technology, Taiwan [104-2112-M-009-008-MY3, 106-2923-M-009-002-MY3, 107-2112-M-009-012-MY3, 106-2314-B-309-001]
A dual-frequency-liquid-crystal (DFLC)-based biosensor was developed and its frequency-dependent dielectric properties were exploited to detect and quantitate a protein standard, bovine serum albumin (BSA). By analyzing the dielectric spectra of DFLC in the presence of BSA at various concentrations, we found that the difference in dielectric permittivity between the high- and low-frequency regimes is correlated to BSA concentration, thereby permitting a DFLC-based protein quantitative method. The dielectric properties of DFLCs are fundamental in the design of liquid crystal displays and fast-switching devices. Results from this study demonstrate the extended potential of the frequency-revertible dielectric anisotropy of DFLC in biosensing and protein quantitation.
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