期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 11, 期 476, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aar4289
关键词
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资金
- University of Washington
- UT Health San Antonio Nathan Shock Centers of Excellence in the Basic Biology of Aging
- NIH [P30AG013280, P30AG013319]
The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer's disease. Despite its compelling preclinical record, no clinical trials have tested rapamycin or other mTOR inhibitors in patients with Alzheimer's disease. We argue that such clinical trials should be undertaken.
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