4.8 Article

Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides

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SCIENCE
卷 363, 期 6433, 页码 1301-+

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AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aar7486

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资金

  1. Swiss National Science Foundation [31003A_127563]
  2. Research Foundation-Flanders [G.0C37.14N, FWO14/PDO/166]
  3. Ghent University Special Research Fund [01J11311]
  4. CLEM grant
  5. Swiss National Science Foundation (SNF) [31003A_127563] Funding Source: Swiss National Science Foundation (SNF)

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Physical damage to cells leads to the release of immunomodulatory peptides to elicit a wound defense response in the surrounding tissue. In Arabidopsis thaliana, the plant elicitor peptide 1 (Pep1) is processed from its protein precursor, PRECURSOR OF PEP1 (PROPEP1). We demonstrate that upon damage, both at the tissue and single-cell levels, the cysteine protease METACASPASE4 (MC4) is instantly and spatiotemporally activated by binding high levels of Ca2+ and is necessary and sufficient for Pep1 maturation. Cytosol-localized PROPEP1 and MC4 react only after loss of plasma membrane integrity and prolonged extracellular Ca2+ entry. Our results reveal that a robust mechanism consisting of conserved molecular components links the intracellular and Ca2+-dependent activation of a specific cysteine protease with the maturation of damage-induced wound defense signals.

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