期刊
SCIENCE
卷 363, 期 6425, 页码 365-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat7554
关键词
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资金
- Sobek Foundation
- Ernst-Jung Foundation
- Deutsche Forschungsgemeinschaft (DFG) (Reinhart-Koselleck-Grant) [SFB 992, SFB1160, SFB/TRR167]
- Ministry of Science, Research and Arts, Baden-Wuerttemberg (Sonderlinie Neuroinflammation)
- European Union [607962]
- Bundesministerium fur Bildung, Wissenschaft, Forschung und Technologie (BMBF)
- DFG [GR4980]
- Behrens-Welse-Foundation
- Max Planck Society
- DFG grant KIDGEM [SFB 1140]
- Centre for Biological Signalling Studies (BIOSS) [EXC294]
- European Research Council (ERC) [337689]
- European Research Council (ERC) [337689] Funding Source: European Research Council (ERC)
The innate immune cell compartment is highly diverse in the healthy central nervous system (CNS), including parenchymal and non-parenchymal macrophages. However, this complexity is increased in inflammatory settings by the recruitment of circulating myeloid cells. It is unclear which disease-specific myeloid subsets exist and what their transcriptional profiles and dynamics during CNS pathology are. Combining deep single-cell transcriptome analysis, fate mapping, in vivo imaging, clonal analysis, and transgenic mouse lines, we comprehensively characterized unappreciated myeloid subsets in several CNS compartments during neuroinflammation. During inflammation, CNS macrophage subsets undergo self-renewal, and random proliferation shifts toward clonal expansion. Last, functional studies demonstrated that endogenous CNS tissue macrophages are redundant for antigen presentation. Our results highlight myeloid cell diversity and provide insights into the brain's innate immune system.
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