期刊
SCIENCE
卷 363, 期 6430, 页码 975-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aau8956
关键词
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资金
- Intramural Research Program of the National Institute for Neurological Disorders and Stroke (NINDS)
- National Institute of General Medical Sciences (NIGMS) [T32 GM007171]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [ZIANS003144] Funding Source: NIH RePORTER
Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain.
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