期刊
RHEUMATOLOGY INTERNATIONAL
卷 39, 期 6, 页码 1027-1036出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-019-04267-y
关键词
Aorta; Carotid arteries; Atherosclerosis; Arterial stiffness; Systemic lupus erythematosus
类别
资金
- National Institutes of Health/National Heart Lung and Blood Institute [RO1-HL04722-01-A6]
- National Center for Research Resources
- National Center for Advancing Translational Sciences [8UL1-TR00004-1]
The progression of atherosclerosis versus arterial stiffness with age within and between arteries has not been defined. Systemic lupus erythematosus (SLE) is a human model of accelerated arterial disease that may permit this determination. 76 SLE patients (69 women, age 37 +/- 12years) and 26 age-and-sex-matched controls (22 women, age 34 +/- 11years) underwent transesophageal echocardiography and carotid ultrasonography for assessment of atherosclerosis [plaques and intima-media thickening (IMT)] and arterial stiffness [increased pressure-strain elastic modulus (PSEM)] of the descending thoracic aorta and carotid arteries. Since IMT is highly associated with plaques, IMT was used as a marker of atherosclerosis to assess its progression in relation with age and PSEM. Aortic and carotid plaques, IMT, and PSEM were greater in patients than in controls (all p0.05). Within the aorta and within the carotid arteries, the average percent increases per decade of age for IMT versus PSEM were similar in patients (8.55% versus 9.33% and 3.39% versus 2.46%, respectively) and controls (5.53% versus 6.60% and 4.75% versus 3.49%, respectively) (all p0.58). However, in SLE patients, the average percent increases per decade of age for IMT and PSEM were higher in the aorta than in the carotid arteries (8.55% and 9.33% versus 3.39% and 2.46%, respectively, both p0.03). In patients with SLE, atherosclerosis and arterial stiffness progress with age parallel to each other within arteries, but divergently between arteries with different anatomy and hemodynamics.
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