期刊
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
卷 52, 期 -, 页码 -出版社
SOC BRASILEIRA MEDICINA TROPICAL
DOI: 10.1590/0037-8682-0225-2018
关键词
Malaria; Plasmodium falciparum; Artemisinin Resistance; Kelch 13
资金
- Evandro Chagas Institute/Brazilian Ministry of Health
- FAPESP (Sao Paulo Research Foundation) [02/9546-1]
- CNPq (National Council for Scientific and Technological Development) [302353/2003-8]
- CNPq
- CAPES (Federal Agency for the Support and Improvement of Higher Education)
- FUNADESP (National Foundation for Development of Private Education)
Introduction: Mutations in the propeller domain of the Plasmodium falciparum kelch 13 (k13) gene are associated with artemisinin resistance. Methods: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. Results: We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples. Conclusions: Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combination therapy.
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