期刊
RESEARCH IN VETERINARY SCIENCE
卷 122, 期 -, 页码 156-164出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2018.11.019
关键词
Dogs; Enteropathy; Gut microbiota; Inflammatory bowel disease; Immune system
Chronic enteropathy (CE) in dogs is a chronic and relapsing immunopathology, of unknown etiology, that usually manifests with a plethora of clinical signs reflecting the underlying heterogeneity in its pathogenesis. Alterations of the mucosal immune responses and the gut microbiota composition are thought to play an essential role in CE. Similar to humans, it is hypothesized that the breakdown in mucosal tolerance leads to aberrant and pathological immune responses toward the gut microbiota, that in turn, may contribute to the severity of disease, at least for certain CE subsets. Therefore, in this review, we discuss some of the most relevant and recent insights microbiological and immunological aspects characterizing CE in dogs.
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