期刊
PSYCHOPHARMACOLOGY
卷 236, 期 3, 页码 989-999出版社
SPRINGER
DOI: 10.1007/s00213-019-05207-1
关键词
Dopamine; Serotonin; Norepinephrine; Synaptosomes; Binding; Analgesia; Stimulant; MEAI
资金
- National Institute on Drug Abuse (NIDA) Intramural Research Program [DA 00523]
- NIDA [R01 DA041336]
- Veteran's Administration VISN 22 Mental Illness Research, Education, and Clinical Center
- NATIONAL INSTITUTE ON DRUG ABUSE [ZIADA000522] Funding Source: NIH RePORTER
RationaleOver the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-aminoindan (2-AI), have been sold as designer drugs. Another aminoindan derivative, 5-methoxy-2-aminoindan (5-MeO-AI or MEAI), is the active ingredient in a product marketed online as an alcohol substitute.MethodsHere, we tested 2-AI and its ring-substituted derivatives 5-MeO-AI, 5-methoxy-6-methyl-2-aminoindan (MMAI), and 5,6-methylenedioxy-2-aminoindan (MDAI) for their abilities to interact with plasma membrane monoamine transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT). We also compared the binding affinities of the aminoindans at 29 receptor and transporter binding sites.Results2-AI was a selective substrate for NET and DAT. Ring substitution increased potency at SERT while reducing potency at DAT and NET. MDAI was moderately selective for SERT and NET, with tenfold weaker effects on DAT. 5-MeO-AI exhibited some selectivity for SERT, having sixfold lower potency at NET and 20-fold lower potency at DAT. MMAI was highly selective for SERT, with 100-fold lower potency at NET and DAT. The aminoindans had relatively high affinity for (2)-adrenoceptor subtypes. 2-AI had particularly high affinity for (2C) receptors (K-i=41nM) and slightly lower affinity for the (2A) (K-i=134nM) and (2B) (K-i=211nM) subtypes. 5-MeO-AI and MMAI also had moderate affinity for the 5-HT2B receptor.Conclusions2-AI is predicted to have (+)-amphetamine-like effects and abuse potential whereas the ring-substituted derivatives may produce 3,4-methylenedioxymethamphetamine (MDMA)-like effects but with less abuse liability.
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