期刊
PROCEEDINGS OF THE NUTRITION SOCIETY
卷 78, 期 3, 页码 313-318出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0029665118002872
关键词
Metabolic-inflammation; Fatty acids; Nod-like receptor family; pyrin domain-containing three protein; IL-1 beta; AMPK
资金
- Science Foundation Ireland principal investigator award [11/PI/1119]
- Joint Programming Healthy Life for a Healthy Diet (JPI HDHL) funded EU Food Biomarkers Alliance 'FOODBALL' [14/JP-HDHL/B3076]
- Irish Department of Agriculture, Food and the Marine [14/F/828]
- Science Foundation Ireland (SFI) [14/JP-HDHL/B3076] Funding Source: Science Foundation Ireland (SFI)
Dietary intake and nutritional status is an important environmental factor which can modulate metabolic-inflammation. In recent years, research has made significant advances in terms of understanding the impact of dietary components on metabolic-inflammation, within the context of obesity, type-2 diabetes (T2D) and CVD risk. Our work demonstrated that different fatty acids differentially modulate metabolic-inflammation, initially focusing on Nod-like receptor family, pyrin domain-containing three protein (NLRP3) inflammasome mediated IL-1 beta biology and insulin signalling. However, the paradigm is more complex, wherein data from the immunology field clearly show that nature of cellular energy metabolism is a key determinant of inflammation. Whilst metabolic-inflammation is a critical biological interaction, there is a paucity of data in relation to the nature and the extent to which nutritional status affects metabolic-inflammation. The complex paradigm will be discussed within the context of if/how dietary components, in particular fatty acids, may modulate obesity, T2D and CVD risk, via inflammatory and metabolic processes.
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