期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 11, 页码 4940-4945出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1809105116
关键词
sORF; peptide; respiration; mitochondria; lipid metabolism
资金
- Boehringer Ingelheim Fond
- Skolkovo Institute of Science and Technology
- Russian Foundation for Basic Research (RFBR) [17-04-01904, 18-29-07005]
- Russian Science Foundation (RSF) [17-75-30027]
- Moscow State University Scientific School
- Russian Ministry of Science Grant [14.W03.31.0012]
- President's Scholarship [SP-4132.2018.4]
- RSF [17-15-01175]
- RFBR [18-54-74003]
- Russian Science Foundation [17-15-01175, 17-75-30027] Funding Source: Russian Science Foundation
Genes coding for small peptides have been frequently misannotated as long noncoding RNA (lncRNA) genes. Here we have demonstrated that one such transcript is translated into a 56-amino-acid-long peptide conserved in chordates, corroborating the work published while this manuscript was under review. The Mtln peptide could be detected in mitochondria of mouse cell lines and tissues. In line with its mitochondrial localization, lack of the Mtln decreases the activity of mitochondrial respiratory chain complex I. Unlike the integral components and assembly factors of NADH: ubiquinone oxidoreductase, Mtln does not alter its enzymatic activity directly. Interaction of Mtln with NADH-dependent cytochrome b5 reductase stimulates complex I functioning most likely by providing a favorable lipid composition of the membrane. Study of Mtln illuminates the importance of small peptides, whose genes might frequently be misannotated as lncRNAs, for the control of vitally important cellular processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据