期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 14, 页码 7095-7100出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1817278116
关键词
working memory; monkey; executive function; neurophysiology; cognitive training
资金
- National Eye Institute of the National Institutes of Health [R01 EY016773, R01 EY017077, R01 MH116675]
The amount of information that can be stored in working memory is limited but may be improved with practice. The basis of improved efficiency at the level of neural activity is unknown. To investigate this question, we trained monkeys to perform a working memory task that required memory for multiple stimuli. Performance decreased as a function of number of stimuli to be remembered, but improved as the animals practiced the task. Neuronal recordings acquired during this training revealed two hitherto unknown mechanisms of working memory capacity improvement. First, more prefrontal neurons became active as working memory improved, but their baseline activity decreased. Second, improved working memory capacity was characterized by less variable temporal dynamics, resulting in a more consistent firing rate at each time point during the course of a trial. Our results reveal that improved performance of working memory tasks is achieved through more distributed activation and invariant neuronal dynamics.
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